ON-DEMAND WEBINAR Use of the Taconic Knockout Mouse Repository in Drug Discovery
Presented by Mr. David Powell
There is strong evidence that mouse knockout phenotypes predict drug action. This webinar highlights a variety of applications and study data demonstrating the utility of Knockout Mouse Repository models.
Key Learning Points:
Data from studies around Diabetes (GTT, glucose and insulin levels), Osteoporosis (BMD), and Dyslipidemia (triglycerides) to show the effectiveness of Knockout Mouse Repository models for target identification
A variety of examples showing how knockout models aid the drug discovery process. Cases such as the use of Angptl3 and Angptl4 from the Knockout Mouse Repository to inject antigen to raise neutralizing antibodies as a general approach to targets for any indication will be described
Tools you can use to suggest the extent of target inhibition required to observe effects
How Knockout Mouse Repository models help determine compound on-target vs off-target effects