The use of genetically engineered mice in experimental medical research has led to significant advances in our understanding of human health and disease.
From the development of transgenic and gene targeting methods to recent innovations in gene-editing technologies, manipulation of the mouse genome has become increasingly sophisticated.
This white paper discusses the available technologies used in the generation of genetically humanized mice and the favored applications of these models in biomedical research.
Types of DNA Vectors for Humanization
How to Apply Genetically Humanized Models in:
- Efficacy and Safety Testing of Therapeutic Compounds and Biologics
- Drug Metabolism and Disposition
- Novel Therapeutic Approaches In Vivo
- The Immune System