Utilizing animal models for immuno-oncology and oncology research is vital for the pre-clinical drug discovery process. Taconic Biosciences is very excited to be virtually participating in this year’s American Association of Cancer Research's Virtual Meeting II. Taconic offers a diverse portfolio of solutions for immuno-oncology and oncology research including, but not limited to, syngeneic tumor models, immunodeficient mice, human immune system engrafted mice and genetically humanized mice. Ask about the new B2m-NOG, an immunodeficient CIEA NOG mouse® with an additional knockout of the B2m gene, which disrupts MHC class I antigen presentation.AACR Virtual Annual Meeting II Abstracts Featuring Taconic Models
Title: 5574 / 7 - In vivo model development for immune cell-based therapeutics
Institution: Intellia, Taconic
Authors: Elizabeth McMichael, Utsav Jetley, Christopher Rudulier, Minasri Borah, Nicole Ganci, Vandhana Ragothaman, Ishina Balwani, Amanda Frain, Priya Pajanirassa, Yuko Miki, Jeffrey Jones, Troy Luster, Marie Keenan, Terina Martinez, Yong Zhang, Birgit Schultes
Model: NOG
Title: 1634 / 25 - Orthotopic and bone metastasis prostate cancer models using the 22Rv1 cell line
Institution: Pharmatest
Authors: Justyna Zdrojeska, Tiina E. Kähkönen, Jenni H. E. Mäki-Jouppila, Masi Valkonen, Pekka Ruusuvuori, Jussi M. Halleen, Jenni Bernoulli
Model: NOG
Title: 6298 / 11 - 2D ex vivo patient derived acute myeloid leukemia platform for evaluation of novel molecular targeted therapeutic agents
Institution: Champions Oncology
Authors: Bhavna Verma, Nikolett Biel, Amy Wesa
Model: NOG, NOG-EXL
Title: 5046 / 3 - Natural Killer (NK) human immune system (HIS) immunograft platform to evaluate the pharmacodynamics of immuno-oncology therapeutics
Institution: Champions Oncology
Authors: Bhavna Verma, Jon Weidanz, Amy Wesa
Model: hIL15-NOG
Title: 585 / 10 - Colitis in tumor-bearing mice undergoing checkpoint inhibitor therapy
Institution: Biomodels
Authors: Caitlin S. L. Parello, Benjamin G. Cuiffo, Kasey Reardon, Alexandria Fusco, Brett Van Dam, Gregory D. Lyng, Stephen T. Sonis
Model: RAGN12
Title: 5059 / 16 - Breast cancer patient-derived xenograft models for pre- and co-clinical investigation of immune based therapies
Institution: EPO Berlin
Authors: Annika Wulf-Goldenberg, Verena Kiver, Maria Stecklum, Bernadette Brzezicha, Philipp Jurmeister, Caroline Schweiger, Jens-Uwe Blohmer, Ulrich Keilholz, Jens Hoffmann
Model: NOG
Title: 5631 / 19 - Leukaemia and lymphoma patient-derived xenografts (PDX) engraft on humanized mice and respond to immune therapy with check point inhibitors
Institution: EPO Berlin
Authors: Maria Stecklum, Annika Wulf-Goldenberg, Antje Siegert, Bernadette Brzezicha, Anja Sterner-Kock, Wolfgang Walther, Jens Hoffmann
Model: NOG