Applications of Transgenic HLA Mice, From Vaccines to Immuno-oncology
Transgenic HLA mice have applications beyond just vaccine research. These mice are able to model the human immune response compared to other preclinical models making them ideal for autoimmune disease research and immuno-oncology studies. Transgenic HLA mice express human leukocyte antigen (HLA) proteins—the human versions of antigen-presenting major histocompatibility complex (MHC) proteins. Antigen binding specificity varies significantly between humans and preclinical model species. This makes the ability of transgenic mice to express human HLA representing an in vivo system for evaluating human antigen presentation valuable.
This webinar will discuss how transgenic HLA mice can be applied to vaccine, autoimmune disease studies and immuno-oncology applications. You will learn more about:
- The HLA/MHC system and HLA classes
- Why transgenic HLA mice express a chimeric human/mouse protein
- Available HLA class I and class II mouse models
- How to work with transgenic HLA mice
Dr. Courtney Ferrebee
Field Applications Scientist | Taconic Biosciences
After earning her PhD in Molecular Medicine, she completed a postdoctoral fellowship at the Emory Vaccine Center where she helped with the development of a DNA-MVA-protein based-vaccine for HIV. Her research background includes various areas of expertise including wound care medical device development, infectious disease and vaccine immunology research, and intestinal biology and bile acid metabolism.