About the webinar:
Genetically engineered mouse colitis models are increasing the flexibility and predictive validity of preclinical colitis models in inflammatory bowel disease (IBD) research. These powerful tools are increasingly supplementing or replacing traditional chemically induced models (e.g. DSS- or TNBS-induced colitis), and offer important translational and mechanistic insights in IBD drug development.
Colitis Models for Preclinical Drug Development
This webinar will introduce the genetically engineered mouse colitis models available from Taconic Biosciences, including Rag2 knockouts (for adoptive T cell transfer and anti-CD40-induced colitis), Mdr1a knockouts, and Il10 knockouts. For each, we will review disease mechanisms, pathological features, endpoints, and critical considerations when planning to add these to your research repertoire.
Watch this webinar to learn about:
- The characteristics and uses of Rag2, Mdr1a, and Il10 knockouts in colitis research; the power of each and how to choose amongst these
- How genetically engineered mouse colitis models compare to standard chemically induced models
- The role of the microbiome in colitis models
- Tips and tricks for getting these models to work in your institution
