Genetically engineered models (GEMs) can increase the flexibility and feasibility of performing advanced syngeneic tumor studies.
However, there are multiple types of models available such as knockouts (KOs), transgenics, and humanized knock-ins (KIs). Depending on your research goals, one specific model might be better suited than another. While standard inbred strains are commonly used, GEMs confer many benefits to syngeneic studies by enabling researchers to use human-specific therapeutics, circumvent species-specific differences, and understand the role of the immune system in the elimination of tumors.
This white paper examines the GEMs available for syngeneic studies and highlights the benefits of each.
Inside, you’ll uncover:
- The benefits of advanced preclinical models in immuno-oncology research
- Which GEMs are most commonly utilized in syngeneic research studies
- How to select the most appropriate tumor model system in which to evaluate immuno-oncology therapeutics
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