Patrick M. Sullivan, PhD
Taconic Biosciences and Dr. Patrick Sullivan, Associate Professor of Geriatrics at Duke University School of Medicine, presented an e-seminar exploring the multiple roles for the APOE targeted replacement mice in Alzheimer's and Cardiovascular disease research.
Learn more about the relationship between APOE genotype and late onset Alzheimer's disease (AD)
The APOE gene is polymorphic; encoding three different alleles designated APOE2/3/4. APOE4 carriers have the highest risk for Alzheimer’s disease while APOE3 carriers have an essentially neutral risk and APOE2 carriers may be protected against Alzheimer’s disease. The APOE4 gene is also linked to increased risk for atherosclerosis, cerebral amyloid angiopathy, peripheral neuropathy, stroke and type II diabetes.
Key Learning Points:
This webinar provided information about how APOE targeted replacement mouse models can be used to advance your Alzheimer’s and Cardiovascular disease research. Among other topics, we discussed:
- The role of apolipoprotein E in Alzheimer’s disease pathology and in cardiovascular disease
- The creation of the APOE2, APOE3, and APOE4 targeted replacement mice and their use in Alzheimer’s research
- The use of APOE targeted replacement mice in heart disease, stroke, TBI, type II diabetes and CAA
