Human APOE Knock-In Mice for Cerebrovascular and Neurodegenerative Disease Modeling
Thursday, March 10, 2022 | 12:00 p.m. PST
Apolipoprotein E (ApoE) is involved in the transport of cholesterol through its interaction with low-density lipoprotein receptor-related protein-1. ApoE is a principal cholesterol carrier within the brain and central nervous system. Three polymorphic isoforms exist in the human population, including ApoE2 and ApoE3, as well as ApoE4, which is the most prevalent genetic risk factor for Alzheimer's disease. The ApoE4 isoform is associated with increased neurodegeneration and cerebrovascular impairments.
- This webinar will introduce Taconic's three targeted transgenic replacement mice and their utility for translational modeling of brain disease involving cerebrovascular dysfunction, accumulation of Aβ, and cognitive decline.
Dr. Fred Beasley
Field Application Scientist | Taconic BIosciences
Dr. Fred Beasley obtained his PhD from Canada's Western University, researching mechanisms of bacterial pathogenesis. Dr. Beasley did postdoctoral work at the University of California and at the Calibr Institute, developing in vivo models of infection and therapy for small molecule immune boosters and antimicrobials. Prior to joining Taconic, he served as the In Vivo Biologist for Jecure Therapeutics, and as a Director of Scientific Engagement at Crown Bioscience.