As drug discovery efforts shift towards increasingly complex and highly specific biologic therapeutics, sourcing appropriate in vivo models for preclinical work is becoming more challenging. Researchers are turning to humanized immune system (HIS) models for help addressing their modern in vivo drug research challenges.
HIS models are invaluable tools for a wide range of research applications, including immuno-oncology, autoimmune disease, infectious disease, and basic research into the immune system and hematopoiesis.
This white paper thoroughly reviews HSC and PBMC engraftment models using the core NOG mouse in addition to next generation models designed to support engraftment of particular human immune cell subsets such as myeloid lineages and NK cells.
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