Non-alcoholic fatty liver disease (NAFLD) is a complex spectrum of disorders ranging from simple benign steatosis to more aggressive forms of non-alcoholic steatohepatitis (NASH) and fibrosis. For researchers studying this condition, diet plays an important role and nutrient modifications can affect how NAFLD presents in animal models. In fact, purified diets formulated with specific nutritional components can drive the entire spectrum of NAFLD in animal models.

Watch this on-demand webinar for an informative discussion co-hosted with Research Diets, Inc., the leading manufacturer of custom, purified OpenSource diets, to learn more about diet-induced NAFLD/NASH models. Sridhar Radhakrishnan, PhD, Project Manager and Scientist at Research Diets, Inc., will outline different dietary approaches for NAFLD development in animal models along with the timeframes required for disease development and whether human-like NAFLD metabolic disease comorbidities also develop.

Key takeaways from this webinar will include:

  • Comparison of different models of NAFLD with details on nutrient modifications in animal diets and timeframes for phenotype development

  • Advantages and disadvantages of different animal models for NASH/fibrosis

  • Tips on NASH model selection including identifying the right animal model/strain and choosing appropriate experimental and control diets


Cindy Besch-Williford Sridhar Radhakrishnan, PhD, Project Manager and Scientist, Research Diets, Inc.
‘Sri’ received his Undergraduate degree in Pharmaceuticals and Fine Chemicals from the Institute for Chemical Technology, Mumbai, India and received his PhD in Food Science and Human Nutrition from Colorado State University. Before joining Research Diets, Sri was a Post-doctoral Scholar in the Department of Food Science, Pennsylvania State University. He has worked with both in vitro and in vivo (mouse and pig) models to screen, evaluate toxicity, study efficacy, and potency of anti-inflammatory and anti-cancer phytochemicals. His background provides him strong credentials and a unique perspective to assist researchers with their laboratory animal diet formulation needs, and he has thoroughly enjoyed helping and collaborating with researchers on different diet induced phenotypes in the last five years at Research Diets, Inc.

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