The advent of immuno-oncology has necessitated changes in the types of animal models used in oncology drug discovery. Syngeneic models—inbred mice bearing an engrafted tumor derived from a genetically identical mouse strain—are invaluable preclinical research tools that enable tumor studies in the context of a complete and functional immune system. These models are powerful tools for studying tumor-immune system interactions and investigation into new immunotherapies.
This white paper takes a closer look at the benefits of syngeneic tumor models and provides:
- An overview of syngeneic tumor models and their importance for immuno-oncology studies
- A brief history of syngeneic models
- The specific differences between syngeneic and humanized models and how this affects their suitability for particular research studies
- The essential considerations to account for in a successful syngeneic tumor study, including genetic background, health status, and the microbiome
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