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Best Practices for Diet-Induced NASH and DIO Studies: How Housing and Husbandry Can Impact Outcomes

Diet-induced mouse models are important tools for metabolic disease research, and experimental outcomes can be greatly affected by housing and husbandry elements.  This is true whether you’re purchasing preconditioned mice or conditioning them in-house. To ensure your experiments run successfully, it’s important to manage factors such as acclimation time, enrichment, cage density and diet.  

 Mice that are fed a high fat diet for prolonged periods can develop aggression and suffer from adverse outcomes such as fight wounds and alopecia. In this webinar, we focus on models of obesity and NASH that are induced by exposure to a high-fat diet. We’ll use the Taconic Diet Induced Obese B6 and Diet Induced NASH B6 as key examples. This webinar empowers you with the critical information you need to plan and successfully execute studies using DIO and NASH mice.  

 

View this webinar to learn:

  • Acclimation, housing and husbandry recommendations for use with Taconic DIO B6 and Diet Induced NASH B6 models
  • How diet selection affects high fat diet-induced metabolic disease models
  • The impact of transit on obese mouse models and how to ensure proper acclimation time
  • The impact of sex, strain, substrain, and thermoneutral housing on high fat diet-induced metabolic disease models
  • How to successfully maintain animals for prolonged periods and reduce adverse outcomes
  • How to account for biological variability

Laura Griffin, PhD

Field Applications Scientist

Dr. Laura Griffin has been working with preclinical models for a decade and is experienced in choosing appropriate models for various research applications. She obtained her PhD in Food Science and Technology at Virginia Tech, where she focused on the mechanisms by which dietary bioactive compounds influence the onset of metabolic syndrome using preclinical models. As a postdoctoral fellow at the Plants for Human Health Institute, her research shifted to focus on the impact of the gut microbiome on metabolism of bioactive compounds. In addition to her expertise in metabolic diseases in preclinical models, Dr. Griffin is also versed in laboratory animal diets and their usage in preclinical applications.

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Taconic preconditioned cohorts can save you time and money.

When conditioning in-house, you plan your study and wait, sometimes for many months.  Once animals are ready, you have limited ability to change your study plan. If you suffer unexpected attrition, you may not be able to execute your study as planned. 

 Taconic DIO and NASH B6 models offer preconditioned cohorts ready when you need them. This enables you to start studies immediately, instead of spending months on conditioning time. You’ll also preserve vivarium space for active studies rather than conditioning cohorts.

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