Transgenic mouse models are crucial to understanding the mechanisms of neurodegenerative disorders like Alzheimer's disease and evaluating efficacious therapies. With this goal in mind, Taconic Biosciences has teamed up with LifeCanvas Technologies to characterize pathological markers of Alzheimer's disease and investigate how the disease progresses using advanced 3D histological technology in two Taconic mouse models: APPSWE and ARTE10 (APP-PS1).
Alzheimer's disease is a multifaceted progressive neurodegenerative disease with many underlying mechanisms. Each preclinical model typically allows for the investigation of a particular hypothesis, such as an assessment of tangles or plaques. Taconic's APPSWE and ARTE10 (APP-PS1) models, which are commonly used for preclinical therapeutic efficacy studies in Alzheimer's disease, both express high concentrations of the β-amyloid precursor protein, resulting in amyloid plaque depositions and reactive glia.
In this webinar, Dr. Moriah Jacobson and Dr. Adam Hall will discuss how the combination of disease-specific mouse models and advanced imaging technology can help researchers gain improved insight into Alzheimer's disease. They will provide an overview of the current available characterization and imaging data of these two mouse models, as well as reveal how 3D imaging technology facilitates the analysis of distribution and density of plaques present in each model at different ages, which can improve the evaluation of potential therapeutics.
View this webinar to:
- Understand how to select a preclinical mouse model for Alzheimer's research, focusing on models that allow plaque development.
- Discover the advantages of 3D histology and imaging compared to traditional 2D immunohistochemistry to study neurodegenerative disease.
- Learn how intact tissue clearing and light sheet imaging can be applied to study protein aggregates and neuroinflammatory markers in Alzheimer's, and to quantify their density and distribution.
