Drug Discovery Applications of Diet Induced Obese (DIO) B6 Mice
Since the 1990s, purified high-fat diets have been used to generate mouse and rat models of obesity. While many variations exist, C57BL/6 mice conditioned on a diet with 60% fat (by kcal) have become a standard model for obesity and metabolic disease studies. In this webinar, you’ll learn about the wide range of uses for the classic DIO B6 model.
The application of DIO mice is much broader than just obesity research. These models are useful for studies across the spectrum of metabolic syndrome phenotypes, including obesity, type 2 diabetes, inflammation, and cardiovascular disease. They’re used for compound screening as well as mechanistic studies. Current trends for DIO mice include the study of obesity as a comorbidity in cancer and other conditions.
View this webinar to learn:
- How the classic DIO mouse is helping to fuel cutting-edge research on the ways obesity impacts cancer and other diseases
- How DIO B6 models are helping researchers to develop new treatments for a wide range of indications
- Key differences between available DIO models, related to substrain and other factors
Ditte Olsen, PhD
Field Applications Scientist
Dr. Ditte Olsen received her Master of Science in Molecular Biology from Aarhus University, Denmark and earned her industrial PhD in Neuroscience from Aarhus University and Lundbeck. During her PhD, Ditte studied the dopaminergic system in various transgenic animal models. During her postdoctoral training, her focus changed to the field of cardiovascular disorders. Following her postdoctoral training, she joined a biotech company where her focus was on preclinical research using small molecules to reduce high cholesterol levels. Ditte brings nearly 15 years of in vivo research experience to her role as a Field Application Scientist at Taconic.
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Why choose Taconic Diet Induced Obesity B6 mice for your study?
The Taconic DIO B6 has unique characteristics that make it an excellent strain for metabolic disease modeling. Taconic B6 mice are available as preconditioned cohorts, so you can start your research right away. This saves you months of conditioning time, and lets you save vivarium space for active studies rather than conditioning cohorts.
Taconic has produced a version of the DIO B6 model since 2005, which academic and industry researchers have used extensively for both basic research and drug discovery.