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Mouse and Rat Model Generation: The Essentials for Success

Genetically engineered mouse and rat models are important tools for both basic research and drug discovery. Due to steady advances in gene targeting technology, increasingly sophisticated and highly customized models can be generated for more precise, targeted preclinical research.

This webinar will cover three major methods for successful generation of custom mouse and rat models, including the individual strengths and limitations of the different options. The choice of which technology to use should be driven by the requirements for your model and experimental goals and is an important first step for efficient and cost-effective generation of your model.

The webinar will also provide insight into how outsourcing model generation to a professional provider with extensive expertise will help mitigate risk and provide you with access to scientific support and veterinary oversight. These elements will ensure that your custom model is available within the anticipated timeline and with the desired modification, thereby increasing the chance for experimental success.

 

Watch this on-demand webinar to:

  • Gain a general understanding of the methodologies for generating genetically engineered mouse and rat models
  • Learn about advantages and disadvantages of these different methods and how using the best-fit methodology ensures success
  • Understand general timelines for specific strategies for custom model generation
  • Learn about the advantages of outsourcing model generation to a professional provider

Dr. Dominique Bröhl

Scientific Program Manager, Custom Model Generation 

Dominique joined Taconic in 2016 after 14 years in academic research. He has expertise in rodent model generation, developmental biology and stem cell biology. He completed a Master’s degree in biology from the University of Bonn (Germany) in 2002, focusing on the in vivo characterization of intermediate filament proteins. He received his Ph.D. in developmental biology from the Free University of Berlin (Germany) in 2008, working on transcription factors regulating the development of the spinal cord. Afterwards he completed his postdoctoral training at the Max-Delbrück-Center for Molecular Medicine (Berlin, Germany) focusing on the role of the Notch signaling pathway in the development of muscle stem cells.

Dr. Benedikt Wefers

Scientific Program Manager, Custom Model Generation Solutions

Dr. Benedikt Wefers is an expert in genome engineering, developmental genetics, and neurobiology with more than 12 years of experience in custom mouse model generation. Before joining Taconic, Dr. Benedikt Wefers was head of the Mouse Genome Engineering Unit at the German Center for Neurodegenerative Diseases (DZNE, Munich, Germany), where he generated >100 mouse disease models for neuroscience research. He received his Ph.D. from the Technical University of Munich in 2011, working on genetic mouse models to better understand emotional behaviors. Afterwards he worked as a postdoctoral researcher at the Helmholtz Munich focusing on the development of new genome modification tools for in vivo gene editing and on improving the efficiency of precise gene targeting.

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