About the webinar:
In this webinar, get up to speed on all things MASH (formerly known as NASH), and prepare to run a successful study with a custom MASH genetically engineered model (GEM).
There are many preclinical models of MASH, using both rats and mice, and novel models continue to be developed. Diet conditioning is a common approach to generate MASH rodents. The starting animal line can be from an inbred strain or outbred stock, a commercially-available GEM strain, or a novel GEM designed to mimic relevant human mutations.
Since a newly generated GEM may exist as only one or more founder animals, it’s important to have a plan to rapidly expand and generate study cohorts in order to meet drug discovery timelines. Generating a new genetically engineered MASH model is just the start. Executing a successful study on the fastest timeline possible requires expertise in model design and generation, innovative breeding plans, and careful project management. This webinar gives examples of model generation and study cohort production for MASH research, and addresses the steps you need to take before you start your study.
Watch this webinar to learn about:
- The various stages of MASH rodent model development, from concept to study-ready
- The impact of a well-planned colony expansion on the overall research timeline
- How to plan ahead for attrition and other factors that can affect your project
- MASH diet types, and considerations for diet ordering, storage, and sterility testing
- Taconic’s capabilities: from design through colony expansion, diet-conditioning and tissue collection
