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Evaluation of the Induction of Protective Immunity Against Pulmonary Cryptococcosis in a Humanized Immune System Mouse Model

Humanized immune system (HIS) mouse models have been critical in the advancement of HIV research and continue to be used to study opportunistic diseases impacting people living with HIV/AIDS. One such opportunistic fungal pathogen is Cryptococcus neoformans (C. neoformans).  

Cryptococcosis infection disproportionately affects individuals with HIV/AIDs. It is the most common mycological cause of meningoencephalitis in this patient group. There is a need to investigate new prophylactic and therapeutic options to tackle this infection due to the development of drug resistance to C. neoformans and the immunocompromised patient’s inability to eradicate the infection. 

Dr. Floyd Wormley is one of the leaders in the field of cryptococcosis infectious disease. His lab recently conducted a study with Taconic’s huNOG-EXL model to examine human pulmonary responses against attenuated strains of C. neoformans in order to define protective immunity and potential human vaccine-mediated immune responses. 

Get insight into how Dr. Wormley modelled this infectious disease in Taconic’s huNOG-EXL, the results of his lab’s study, and considerations when selecting a humanized immune system model for your research. The webinar will be followed by a Q&A section – we encourage all to participate! 

Watch the webinar to:

  • Discover the potential of humanized immune system models for infectious disease applications.
  • Get a better understanding of how to model infectious diseases in humanized mice.
  • Hear about the latest research into cryptococcosis infection from one of the field’s leading experts.
  • Explore Taconic’s humanized immune system model portfolio.

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Floyd Wormley Headshot

Floyd Wormley, PhD

Associate Provost for Research, Dean of Graduate Studies at Texas Christian University

Dr. Floyd Wormley's research focuses on development of new vaccines and therapies to prevent and treat invasive fungal infections. He received his PhD in Microbiology/Immunology from the Louisiana State University (LSU) Health Sciences Center. After completing postdoctoral training in infectious diseases at Duke University Medical Center, he joined the University of Texas, San Antonio (UTSA), where he served as assistant, associate, and full professor within the Department of Biology, before being appointed Associate Dean for Research and Graduate Studies within the College of Sciences. Currently he is the Associate Provost for Research and Dean of Graduate Studies at Texas Christian University (TCU). His research background includes microbial pathogenesis, medical mycology, host-pathogen interactions, mucosal immunology, and vaccine development.

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