The mouse stands as a critical tool in advancing preclinical immunological research. However, disparities in immunological signaling cascades and the innate immune response between mice and humans can lead to non-translatable preclinical results. The development of complex humanized immune system (HIS) mice addresses this issue with predominant success in immuno-oncology research applications, and limited validation in autoimmune disease studies so far.

 

Toll-like receptors (TLRs) play a central role in innate human response, but species differences can obscure preclinical investigations targeting human TLR drug discovery. This webinar will delve into the effective utilization of a human-specific TLR4 agonist in HIS mice as a platform for drug discovery focused on the human innate response.

 

Explore the development of a preclinical mouse model for profiling therapeutics directed towards targets in the human TLR4 pathway, building upon a HIS mouse with human myeloid and lymphoid cells. Learn how the use of a human-specific test molecule in a system with the presence of primarily human immune cells minimizes the contribution of murine TLR4 signaling and allows study of human targets in an in vivo preclinical model.