Humanized Mouse Models for Drug Discovery: The NOG Portfolio
As drug discovery efforts rapidly shift towards increasingly complex and highly specific biologic therapeutics, sourcing appropriate in vivo models for preclinical work is becoming more challenging. Researchers are turning to humanized immune system (HIS) models for help addressing their in vivo drug research challenges.
Humanized Mouse Models for Drug Discovery
HIS mouse models have become invaluable tools for a multitude of research applications, ranging from immuno-oncology, autoimmune disease, infectious disease, to basic research into the immune system and hematopoiesis.
Discover how NOG mice can be utilized to accelerate preclinical research and drug discovery. This free white paper provides a thorough overview of HSC and PBMC engraftment models using the original NOG mouse, in addition to next generation models designed to support engraftment of particular human immune cell subsets, such as myeloid lineages and NK cells.
Read this white paper to:
- Get insight into the comprehensive NOG Portfolio and the application of NOG strains as hosts for immune system humanization
- Learn about key alternative cell humanization approaches to address requirements for particular human cell types
- Find out how to select the most appropriate humanized model for your drug discovery needs
- Get detailed guidance to help you maximize the success of your next study utilizing humanized immune system mouse models
Get Access Here
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About The Authors
Ivan Gladwyn-Ng, PhD
Associate Director, Field Application Sciences