Safeguarding Genetic Integrity for Preclinical Research with Rodent Models: Processes and Technologies - Part 1
- How background strain and substrain can impact the expressed phenotype of a mutation
- The reasons why you should always verify background strain upon receipt of a new line
- How to breed and maintain colonies of genetically engineered animal models with appropriate controls for genetic quality
- How genetic drift occurs, and how certain husbandry practices can either help prevent or exacerbate this problem
- The ways colony size and physical location can impact the genetic risk profile of a project
Secure Your Spot
Bart Smits, PhD
Senior Manager Genetic Sciences and Compliance
Dr. Bart MG Smits currently leads the Department of Genetic Sciences and Compliance at Taconic Biosciences. He has 20+ years of research experience with genetically engineered rodent models of human health and disease. Early in his career, Dr. Smits pioneered the generation of genetically engineered rat models, and since then, he has continuously performed research on the cutting edge of rodent genetic engineering.
Before joining Taconic Biosciences in 2018, he was an Assistant Professor at the Medical University of South Carolina in Charleston, leading a research laboratory focusing on comparative genetics of breast cancer susceptibility loci. He completed a postdoctoral research fellowship at the University of Wisconsin-Madison. He holds a PhD in Functional Genomics from the Hubrecht Institute for Developmental Biology and Stem Cell Research in Utrecht, The Netherlands.