Genetic integrity of rodent breeding colonies has a direct and fundamental impact on the quality of preclinical research. Without a robust breeding program which incorporates husbandry best practices, colony refreshment strategies, along with monitoring techniques, critical studies can be undermined by strain contamination, genetic drift and expression changes. These challenges apply to all rodent research, but small GEM colonies are often most at risk.      

Are there surprises hiding in your GEM colonies? Different types of mutations, such as randomly integrated transgenes and CRISPR mutants, require different approaches to genetic monitoring. Strain background can have an unexpected impact on the phenotypic expression of certain mutations, including altering disease severity. Taconic's SNP service often identifies unexpected strain findings in imported lines for biomedical researchers with whom we work. 

Join this webinar series to discover how Taconic Biosciences applies robust strategies to assess, monitor, and maintain genetic quality in both commercial animal model colonies and customer breeding projects. Discover how you can take these strategies and apply them to your own breeding projects. We will provide guidance on best practices ranging from technical solutions, to key husbandry practices and colony refreshment strategies that support genetic quality.  

This series includes two webinars: