Humanized Immune System (HIS) mouse models are useful preclinical tools to further understand the immune system, and many valuable HIS models are generated from the severely immunodeficient CIEA NOG mouse® and related host strains.  The NOG mouse is the base of a flexible platform that includes a variety of 2nd generation strains. 

This series of three webinars will present a thorough overview of the NOG Portfolio, including an overview of humanization approaches to include humanization using PBMCs, HSCs, and isolated primary cells.  HIS mouse engraftment profiles are host strain-specific and can be influenced by the engraftment protocol and individual donors.  Attendees will understand which host strain and humanization approach to select in order to achieve engraftment with relevant human immune cells of interest along with the strengths and limitations of various models.  

This webinar series will include some discussion of the utility of HIS mice for immuno-oncology efficacy studies for therapeutics with a range of mechanisms, including TIL and CAR-T cell therapies, NK cell therapies and NK cell modulators, and more.